The no-hit zone frequency hopping sequence is a sequence with zero collisions between sequences within a certain delay range, and has broad prospects in quasi-synchronous frequency hopping communication systems. To reduce frequency interference among users caused by the increase in user numbers in a frequency-hopping communication system, this article implements a no-hit zone frequency hopping sequence generation method based on matrix transformation, with variable no-hit zone range and sequence quantity, and illustrates the construction process with examples. At the same time, a high-complexity RS code was constructed as a comparison in this article, and the error rates of the two were compared through simulation under different signal-to-noise ratios and user numbers. The results showed that when accessing the frequency hopping network within the no-hit zone range, the hopping system using the no-hit zone hopping sequence had a lower error rate than the hopping system using RS code, greatly enhancing the multi-access communication capability of the hopping system.