The high-precision navigation of the remote sensing instruments onboard FengYun-4 (FY-4) geostationary meteorological satellite is the basis for instrument calibration, product retrieval, and quantitative application. The geosynchronous interferometric infrared sounder (GIIRS) onboard FY-4 satellite, the new generation geostationary meteorological satellite in China, is the first hyperspectral vertical detector operating in the geostationary orbit in the world. In the process of hyperspectral detection, it is key to keep the "resident" observation target stable with high precision. The FY-4 satellite uses an advanced three-axis stable attitude control platform, which brings great flexibility to earth observation and great challenges to the high-precision navigation of the GIIRS. The stability of the high-precision observation target requires the cooperation of satellite platform, attitude control, the instrument and the ground system, which process is very complicated.Based on the introduction of the detection principle and working mode design of the GIIRS, the key technology of satellite-ground integrated navigation is researched. The resident accuracy as well as the navigation accuracy are tested and analyzed using the measured data from the GIIRS in orbit. The results show that the GIIRS achieves a resident accuracy of 1/10 pixel and a navigation accuracy of 1 pixel, laying a good foundation for quantitative applications including numerical weather prediction.