Satellite resources on board are limited and precious, and ground terminals in real communication scenarios have different geographic distribution and satellite communication service demands, so dynamic on board satellite resource management is needed to design flexible and efficient resource management schemes. In this paper, the use of hopping beam technology can provide flexible resource management at the beam level to solve the problem of unbalanced service demand between ground cells covered by point beams generated by high-throughput satellites. Firstly, in order to solve the problem of co-channel interference in beam-hopping satellites, an interference avoidance strategy between beam-hopping clusters based on frequency mode switching is proposed. Further, two cluster configuration strategies, uniform and non-uniform clustering, are proposed. In order to solve the problem of poor equalization effect of uniform clustering and unsuitable for the dynamic change of the ground, combined with the problem of co-channel interference, a non-uniform cluster configuration strategy based on frequency mode switching is proposed for the interference avoidance strategy between beam-hopping clusters.Finally, the interference avoidance strategy is verified and simulated.Besides,the different clustering strategies are verified based on various intelligent optimization algorithms. The simulation results verify the feasibility of the clustered configuration and show that the non-uniform clustering algorithm with no distance limitation has the strongest flow-balancing ability.