With the improvement of space product models, it's more and more general to output digital data from system single machine, and frame structures of digital data are various and different between space products. So it brings huge challenge for the telemetry data processing to process all kinds of digital data frames. If the parsing method for digital data frames is non-uniform, data processing software needs constant adaptable modification, which causes big software maintenance and mistakes easily. In view of this situation, based on summarizing the characteristics of the pre-exist digital data frame structures and the corresponding processing methods, the paper proposes the general parsing method for digital data frames based on multiple-factor combination, which analyzes the use of each factor for parsing digital data frames, and discusses the design and judging of block head and step factors, and puts forward general fulfil process. The method has been used in data processing in space tasks and has received perfect effect.