The existing spacecraft testing and operation management procedures are described in natural language through word documents. Not only it requires manual input, integration and verification, and is a waste of manpower and time, more importantly, it prone to errors due to human reasons, and is not conducive to rapid interaction of the management program among multiple users. In response to this problem, drawing on the experience of spacecraft instruction design such as PLEXIL, PLUTO, Timeliner-TLX, and SCL of NASA and ESA, the spacecraft instruction technology for spacecraft ground testing and on-orbit operation management is studied. The instruction has modularization, abstraction and other high-level programming language features, and has the ability to detect the working process of the spacecraft and handle abnormal states, which is convenient for the human-computer interaction, digital designing, data sharing, interpretation and execution of spacecraft testing and operation management programs. The instruction also can be used as technical reference for spacecraft testing and operation management programs' designing.