This paper combines the development trend of launch vehicles at home and abroad, sorts out the application requirements of the current rocket telemetry system and puts forward a design scheme of the general rocket borne data acquisition and transmission equipment based on VPX bus architecture. The key technologies such as structure standardization technology, bus generalization technology and modularization technology are emphatically analyzed. The scheme unifies the system architecture state of the equipment on the rocket, greatly improves the performance, integration and versatility of the equipment, meets the needs of future model application, and has broad development prospects in the aerospace filed. At last, the advantages of the general rocket borne data acquisition and transmission equipment compared with the existing products are given.