This paper, with the help of model-based systems engineering MBSE idea and information means, takes the model as the core, relationship traceability as the means, and integrates the technical indicators, design experience and other knowledge information of TT&C subsystem. A modeling and design solution of small satellite TT&C subsystem based on MBSE is proposed. Using model carrying documents, combined with explicit experience, information, relationship, it forms knowledge management tools, which improve the work efficiency, and the liberation of the designer, and realizes digital model-based bearing of knowledge and experience. It has been explored and tried for the small satellite measurement and control subsystem from experience design to simulation design transformation, from document-based to model-based development mode, from physical verification to the combination of virtual and physical verification.