The missile telemetry system is mainly used to complete the acquisition, compilation, modulation and transmission of missile flight test data in the process of missile flight test, and cooperate with ground telemetry equipment to complete the remote acquisition of test data, that is, telemetry task. Telemetry data provides data basis for missile and subsystem design verification, fault analysis and test conclusion evaluation. It is an extremely important and essential measurement system in the process of missile development. Combined with the development trend of Missile Telemetry System Technology and the author's innovative engineering design experience in recent years, this paper expounds in detail the overall key technologies including missile telemetry system architecture design, programmable acquisition and editing technology, optimized power supply technology and RF integrated technology, so as to provide a new idea for the overall design of missile telemetry system.