In order to realize the miniaturization of telemetry system, this paper introduces an integrated data acquisition device, which is used for centralized processing of multi-type sensors’ signals, and uploading the collected data to telemetry system. The device is designed with modularity and expansibility, including power supply unit, data processing unit and sensor signal conversion unit according to functions. Through module combination and software interface configuration, it can meet the requirements of different projects. Spacecraft environmental suitability design is applied to optimize the design. The device has been applied to projects in several types. It has the characteristics of small volume, low power consumption, light mass, good flexibility, etc.