The space-based TT&C and communication application for manned space flight are summed up, both at home and abroad. The development of tracking and data relay satellite system is proposed, and the advantages of navigational satellite and LEO satellite constellation systems are discussed, in response to the high requirements of TT&C for China’s manned space flight. Orbital positions adjustment and deploying laser link on tracking and data relay satellite system, and using S-band multiple access (SMA) panoramic beam to monitor manned spacecraft at anytime and anyplace are needed. Navigational satellite and LEO satellite constellation systems are necessary supplements. These space-based TT&C and communication approaches are more flexible, usable and higher cost-effectiveness for manned space flight. The conclusion can provide reference bases for subsequent development of the space-based TT&C and communication for manned space flight.